Vascular ChallengeRoadmapping Workshop

Held on November 9-10, 2016, at the
NASA Ames Research Park, Mountain View, California

The Vascular Tissue Challenge Roadmapping Workshop examined in great detail the state of the art technology in thick-tissue vascularization and 3D tissue engineering. As well as mapping out the pathways, milestones, and challenges towards ending the organ shortage benefiting from these technologies.

The goal of this workshop was to guide future research efforts and encourage new support in bringing about the end-product technologies for patients in need.

The workshop gathered together a diverse network of experts in tissue engineering, microgravity research, and other areas of interest to the advancement of tissue engineering technology. Throughout the two-day workshop, we enjoyed hearing from leading researchers who are working hard to advance this state of the art technology. These subject matter experts also participated in various roundtable discussions to identify the challenges, map out the future pathways, and milestones that would take us to the ultimate solution.

We greatly benefitted from the their vast knowledge and expertise during the entire workshop. We are confident that you will too. Please click on the links below to enjoy a few highlights from the Vascular Tissue Challenge Roadmapping Workshop.

Beta Roadmap Report from the
December 2014 - July 2015
Roadmapping Process including
the the NSF-Funded Washington D.C.
Workshop and White House Roundtable

Workshop Recap

Day 1

SESSION 1: STATE OF THE ART IN THICK-TISSUE VASCULARIZATION (CHAIR JOSHUA NEUBERT)

SESSION 2: VTC TEAM PRESENTATIONS (CHAIR MONSI ROMAN)

  • 1:00 The Challenges of Vascularizing Engineered Heart Tissue
    • Dr. Ming-Sing Si, University of Michigan, VTC Team Leader
  • 1:20 Wake Forest University's Bioprinting Capabilities
    • Dr. Sang-jin Lee, Wake Forest University, VTC Team Leader
  • 1:40 Penn State University, VTC Team Presentation
    • Dr. Ibrahim Ozbolat, Penn State University, VTC Team Leader

SESSION 3: ROADMAPPING ROUNDTABLES 2: OVERCOMING CHALLENGES (CHAIR SCOTT COLLINS)

  • 2:00 Roadmapping Roundtables 2: Overcoming the Challenges

    This Roadmapping session will explore the specific tools and techniques that researchers may use to overcome the challenges along each research pathway to achieve thick-tissue vascularization, and begin looking beyond this technology toward its end-products for use in the marketplace.

    • Roundtable Facilitators lead discussions at tables

SESSION 4: VTC TEAM PRESENTATIONS (CHAIR MONSI ROMAN)

SESSION 5: ROADMAPPING ROUNDTABLES 3: BEYOND THICK TISSUE VASCULARIZATION (CHAIR SCOTT COLLINS)

  • 3:20 Roundtable Discussions 3: Beyond Thick Tissue Vascularization

    This Roadmapping session will focus discussions on defining End-Products for tissue engineering technologies and their benefits and applications. Discussions will also focus on defining the research pathways available in using thick-tissue vascularization technologies to get to these end-product and explore how current research efforts in achieving thick-tissue vascularization could impact the future opportunities to get to specific end-products.

    • Roundtable Facilitators lead discussions at tables

Day 2

SESSION 9: INVESTING IN THE FUTURE (CHAIR LINA CONSTANTINOVICI)

CLOSING PROGRAM

Organizing Committee

Lt. Col. Luis Alvarez

Lt. Col. Luis Alvarez

Academy Professor & Director, Center for Molecular Science, U.S Military Academy; Founding Principal Investigator, Regenerative Biology Group, National Cancer Institute

Dr. Scott Collins

Dr. Scott Collins

CTO, TeVido Biodevices
New Organ Alliance, Roadmap Chair

Dr. Ioana Cozmuta

Dr. Ioana Cozmuta

Industry Innovation & Microgravity Lead,
NASA, Space Portal Office

Dr. Wendy Dean

Dr. Wendy Dean

Medical Officer, DoD USAMRMC
VT Challenge, Judging Committee

Mr. David Gobel

Mr. David Gobel

CEO, Methuselah Foundation
 

Dr. Timothy Hammond

Dr. Timothy Hammond

Professor, Duke University Veterans Affairs Medical Center
VT Challenge Judging Committee

Mrs. Lynn Harper

Mrs. Lynn Harper

Lead for Integrative Studies, NASA Space Portal; NASA Challenge Administrator, VT Challenge.

Dr. Antony Jeevarajan

Dr. Antony Jeevarajan

Deputy Division Chief, Biomedical Research & Environmental Sciences, NASA JSC

Dr. Armand Keating

Dr. Armand Keating

Professor, University of Toronto
VT Challenge, Judging Committee

Mr. Joshua Neubert

Mr. Joshua Neubert

CEO, Institute of Competition Sciences
Managing Partner, New Organ Alliance

Dr. Maria Rapoza

Dr. Maria Rapoza

Executive Director, Duke University
Cardiovascular Research Center

Mrs. Monserrate Roman

Mrs. Monserrate Roman

Director, NASA Centennial Challenges Program

 

Dr. Boris Schmalz

Dr. Boris Schmalz

Research Associate, Max Planck Institutes
Coordinator, New Organ Alliance

Lina Constantinovici

Lina Constantinovici

Founder, Innovation4.4;
Partner, BVC Fund, Founder, Startup Nectar

Mrs. Jana Stoudemire

Mrs. Jana Stoudemire

Life Sciences Lead, Center for the Advancement of Science in Space

Additional Participants

Dr. Keith Murphy

CEO, Organovo

Dr. Michael Roberts

Deputy Chief Scientist, CASIS

Dr. Kevin Healy

University of California, Berkeley

Dr. Yunzhi Yang

Stanford University

Dr. Michele Grimm

Program Manager, NSF BME

Mr. Jedd Lewis

Executive Director, Organ Preservation Alliance

Dr. Melanie Matheu

Founder, Prellis Biologics

Dr. David Fyhrie

UC Davis; NSF BMMB

Dr. Brenda Ogle

University of Minnesota

Dr. Yong Huang

University of Florida

Dr. Ngan Huang

Stanford University

Dr. Joseph Wu

Stanford University

Dr. Todd McDevitt

UCSF, Gladstone Institutes

Partners & Supporters

  • National Science Foundation
  • Center for the Advancement of Science in Space
  • NASA Centennial Challenges Program
  • Duke University Cardiovascular Research Center
  • Organ Preservation Alliance
  • Methuselah Foundation

Sponsors

Roadmap Background

Our Roadmap to Ending the Organ Shortage is organized at the top level into three solution spaces: (1) Tissue Engineering, (2) Increased Access, and (3) Mechanical Replacement. Within each of these categories there are several pathways and many milestones along those pathways which may lead to the ability to produce the tissues and organs required to end the organ shortage.

Tissue Engineering
  • 3D Bioprinting & Manufacturing
  • Cellular Therapies
  • In-Vivo Regeneration
  • Transgenic Generation & Transplantation
Increased Access
  • Cryopreservation
  • Improved Transport
  • Increased Organ Donations
Mechanical Replacement
  • Internal Mechanical Support Systems
  • External Mechanical Support
  • Full Organ Mechanical Replacement

Each workshop in the New Organ Alliance's Roadmapping initiative explores the details of a specific pathway, milestone, or organ system and examines the relationships between the existing state of the art and what is needed to end the organ shortage. The Roadmap was initiated in May 2015 through a workshop coordinated with the Organ Preservation Alliance. Initial results from that workshop can be found in the report below.

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